HRID255366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID21873668

2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

C8H7NO3

HCID23670382

未命名化合物

HCID57815394

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc2ncc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1

HCID24866867

4-[2-[4-[[(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methyl]amino]piperidin-1-yl]ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

C23H28N6O4

收率 64.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

4-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one (Intermediate 202, 75 mg) was reacted with 2,3-dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde (WO 2004/058144) (48 mg) and sodium acetoxyborohydride (0.11) as described for Example 107. Chromatography on silica gel with 0-2% methanol in dichloromethane to give 72 mg of the product.