Triethylamine → 2-{4-[(tert-Butoxycarbonyl)amino]piperidin-1-yl}-1-methylethyl methanesulfonate

Beteiligte Stoffe

Reaktionsschritte

tert-Butyl [1-(2-hydroxypropyl)piperidin-4-yl]carbamate (Intermediate 224, 1.1 g, 4.3 mmol), triethylamine (0.90 mL, 6.5 mmol) and methanesulfonyl chloride (0.37 mL, 4.7 mmol). Were reacted as described for Intermediate 6. The crude mesylate was directly used for the next step.

Herkunft & Nachweise