Isopropyl iodide → Ethyl 2,6-bis(trifluoromethyl)-4-isopropoxy-3-pyridinecarboxylate

HRID 255401Notes

Reaction equation

[F:1][C:2]([F:20])([F:19])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([OH:14])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1.I[CH:22]([CH3:24])[CH3:23]>>[F:20][C:2]([F:19])([F:1])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:14][CH:22]([CH3:24])[CH3:23])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 178470034HCID 178470034, compound

Product 1

HCID 13882868Ethyl 2,6-bis(trifluoromethyl)-4-isopropoxy-3-pyridinecarboxylateYield 74%

Procedure

Following the procedure of Example 4, this material was prepared in 74% yield from product of Example 2 and 2-iodopropane as a liquid, nD25 1.4210. Anal. Calc'd. for C13H13F6N1O3 : C, 45.23; H, 3.80.

Sources & evidence

ORD record: ord-1a80bc1a164f49d18099bc4bddeb0f2c
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04698093

Reaction notes

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