N-Methylethylamine → 3-Ethyl 5-methyl 6-(chlorodifluoromethyl)-4-(N-ethyl-N-methylamino)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate

Participants

Reaction Steps

This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 28, 1.54 g (0.026 mol) of N-ethylmethylamine in 30 ml of DMF were reacted at room temperature for 16 hours affording a residue which was kugelrohr distilled at Pa, pot temperature 104° C., to give 4.7 g of oil. Purification by HPLC using 5% ethyl acetate/cyclohexane as eluting solvent afforded 4.0 g of oil which was purified by kugelrohr distillation at Pa, pot temperature 107° C., to give 3.85 g (70.7%) of product as a yellow solid; mp 33°-35° C.

Provenance & Evidence