HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane | HCID 20165736 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane | HCID 20165755 | — |
Reaction Steps
N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane is dissolved in trifluoroacetic acid and stirred overnight. The solution is poured into water and neutralized with 20% aqueous KOH. The mixture is extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to give 1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04698231 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-1a1f9a151e464812b3c202bdce184c17 |
| Source note | uspto-grants-1987_10 |