反应详情

To a solution of 5.6 g of N-[3(R,S)-hydroxytetradecanoyloxy]succinimide in 150 ml pyridine cooled to 0° are added 4.9 g of tetradecanoylchloride and the reaction mixture maintained at 4° for 12 hours. Excess reagent is destroyed with water, the mixture concentrated by evaporation and the residue chromatographed over silica gel (toluene/ethylacetate=95/5) to obtained the title compound as a syrup.

1. temperaturethe reaction mixture maintained at 4° for 12 hours
2. customExcess reagent is destroyed with water
3. concentrationthe mixture concentrated by evaporation
4. customthe residue chromatographed over silica gel (toluene/ethylacetate=95/5)