反应详情

One hundred twenty-one grams of 1-methoxy-4-(3-n-propylamino)propyl-1,4-cyclohexadiene were dissolved in 1 l. of 15% aqueous sulfuric acid. The acidic solution was refluxed for about 6 hours and was then poured over ice. The dilute acidic solution was made basic with 50% aqueous sodium hydroxide. The now-basic aqueous solution was extracted with methylene dichloride. The methylene dichloride extract was dried and the solvent removed therefrom to yield 25.6 g of cis-(±)-1-n-propyl-7-oxodecahydroquinoline.

1. temperatureThe acidic solution was refluxed for about 6 hours
2. additionwas then poured over ice
3. extractionThe now-basic aqueous solution was extracted with methylene dichloride
4. extractionThe methylene dichloride extract
5. customwas dried
6. customthe solvent removed