Acetic Anhydride → HCID 178432361, compound

HRID 255528Notes

Reaction equation

[CH3:1][N:2]1[C:14]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N+:7]([O-])=[CH:6][C:5]=2[N:4]=[C:3]1[CH3:16].C(OC(=O)C)(=[O:19])C>>[CH3:1][N:2]1[C:14]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[C:6]([OH:19])[C:5]=2[N:4]=[C:3]1[CH3:16]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 10059063HCID 10059063, compound

Product 1

HCID 178432361HCID 178432361, compound

Procedure

Using the method of Example 133, 1,2-dimethyl-1H-imidazo[4,5-c]quinolin-5-oxide (from Example 91) was reacted with acetic anhydride to provide 1,2-dimethyl-4-hydroxy-1H-imidazo[4,5-c]quinoline, m.p. >300° C. Analysis: Calculated for C12H11N3O: %C, 67.7; H, 5.2; %N, 19.7; Found: %C, 67.1; %H, 5.1; %N, 19.5.

Sources & evidence

ORD record: ord-db0dde5e8db942d78d7754fde9da2319
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04698348

Reaction notes

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