Acetic Anhydride → HCID 178521243, compound

HRID 255530Notes

Reaction equation

HRID 255530 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N+:9]([O-])=[CH:8][C:7]=2[N:6]=[CH:5]1.C(OCCN1C2C3C=CC=CC=3N=C(Cl)C=2N=C1)(=[O:25])C1C=CC=CC=1.C(OC(=O)C)(=O)C>>[OH:25][C:8]1[C:7]2[N:6]=[CH:5][N:4]([CH2:3][CH2:2][OH:1])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 139584251-(2-benzoyloxyethyl)-4-chloro-1H-imidazo[4,5-c]quinolineHCID 201835971-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-5-oxide

Product 1

HCID 178521243HCID 178521243, compound

Procedure

Using the method of Example 133, 1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-5-oxide prepared by hydrolysis of the compound of Example 120 was reacted with acetic anhydride to provide 4-hydroxy-1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinoline.

Sources & evidence

ORD record
ord-2ab9d3b61fd74498a2f6e9ee2e278d6e
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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