Formic Acid → HCID 13958440, compound

HRID 255531Notes

Reaction equation

[NH2:1][C:2]1[C:3]([CH3:19])=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][CH:14]([OH:17])[CH2:15][OH:16])=[CH:9][C:8]([F:18])=[CH:7][CH:6]=2.[CH:20](O)=O>>[OH2:16].[OH:17][CH:14]([CH2:15][OH:16])[CH2:13][N:12]1[C:11]2[C:10]3[CH:9]=[C:8]([F:18])[CH:7]=[CH:6][C:5]=3[N:4]=[C:3]([CH3:19])[C:2]=2[N:1]=[CH:20]1

Participants

Reactant 2

HCID 284Formic Acid

HCID 20183625HCID 20183625, compound

Product 1

HCID 13958440HCID 13958440, compound

Procedure

Using the method of Example 137, 3-amino-4-(2,3-dihydroxypropylamino)-6-fluoro-2-methylquinoline (from Example 42) was reacted with formic acid to provide 1-(2,3-dihydroxypropyl)-8-fluoro-4-methyl-1H-imidazo[4,5-c]quinoline hydrate, m.p. 237°-239° C. Analysis: Calculated for C14H14FN3O2.H2O: %C, 57.3; %H, 5.5; %N, 14.3; Found: %C, 57.6; %H, 5.4; %N, 14.4.

Sources & evidence

ORD record: ord-5f85bccd46c94726adddd24dab2d5354
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04698348

Reaction notes

Loading…