Formic Acid → HCID 13958442, compound

HRID 255532Notes

Reaction equation

HRID 255532 reaction equation
[NH2:1][C:2]1[C:3]([CH3:21])=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:9][C:8]([F:20])=[CH:7][CH:6]=2.[CH:22](O)=[O:23]>>[OH2:23].[CH2:13]([N:12]1[C:11]2[C:10]3[CH:9]=[C:8]([F:20])[CH:7]=[CH:6][C:5]=3[N:4]=[C:3]([CH3:21])[C:2]=2[N:1]=[CH:22]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 20183618HCID 20183618, compound

Product 1

HCID 13958442HCID 13958442, compound

Procedure

Using the method of Example 138, 3-amino-4-benzylamino-6-fluoro-2-methylquinoline (from Example 45) was reacted with formic acid to provide 1-benzyl-8-fluoro-4-methyl-1H-imidazo[4,5-c]quinoline hydrate, m.p. 178°-181° C. Analysis: Calculated for C18H14FN3.0.25H2O: %C, 73.1; %H, 4.9; %N, 14.2; Found: %C, 73.0; %H, 4.7; %N, 14.3.

Sources & evidence

ORD record
ord-d1db099e6a7541d3bee1e6fb9f5b40c8
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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