Acetic Anhydride → HCID 178448615, compound

HRID 255555Notes

Reaction equation

HRID 255555 reaction equation
[CH2:1]([N:5]1[C:17]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N+:10]([O-])=[CH:9][C:8]=2[N:7]=[CH:6]1)[CH:2]([CH3:4])[CH3:3].C(OC(=O)C)(=[O:21])C>>[OH:21][C:9]1[C:8]2[N:7]=[CH:6][N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:17]=2[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 118315721-isobutyl-1H-imidazo[4,5-c]quinoline-5-oxide

Product 1

HCID 178448615HCID 178448615, compound

Procedure

Using the method of Example 133, 1-isobutyl-1H-imidazo[4,5-c]quinolin-5-oxide (from Example 74) was reacted with acetic anhydride to provide 4-hydroxy-1-isobutyl-1H-imidazo[4,5-c]quinoline, m.p. >300° C. after recrystallization from N,N-dimethylformamide. Analysis: Calculated for C14H15N3O: %C, 69.7; %H, 6.3; %N, 17.4; Found: %C, 69.8; %H, 6.4: %N, 17.6.

Sources & evidence

ORD record
ord-060377e6008544ae9f1ff9dbe5213303
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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