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HRID25556

反应详情

EQUATION

反应方程式

HRID 25556 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Cl)c1ccc(F)cc1F
HCID2734273

2,4-Difluorobenzenesulfonyl chloride

C6H3ClF2O2S

结构：CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
HCID178484847

未命名化合物

PRODUCTS

生成物

1
结构：CN([C@H]1CC[C@H](OCCCCBr)CC1)S(=O)(=O)c1ccc(F)cc1F
HCID178484849

未命名化合物

PROCEDURE

实验过程

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 2,4-difluoro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-2,4-difluoro-N-methyl-benzenesulfonamide which was used directly in the next steps see Example 12.57-12.58 and 12.65 and 12.66.