2-Mercaptobenzoic Acid → HCID 13770735, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,4-dichlorobenzoic acid (7.64 g), thiosalicylic acid (7.16 g), anhydrous potassium carbonate (22 g), and copper powder (300 mg) was suspended in benzyl alcohol and this suspension was heated under N2 atmosphere at 110-120° C. for 3 hours. After cooling, 10% aqueous potassium hydroxide solution (120 ml) was added and extracted with ether. The aqueous layer was filtered and acidified with 6N HCl. The resulting precipitated product was isolated by filtration. Recrystallization from aqueous methanol gave 4-chloro-2,2'-thiodibenzoic acid (compound No. 1) in an amount of 8.56 g (yield: 70%). m.p. 241-242° C.

Provenance & Evidence