反应详情

To a solution of 1,3-diethoxycarbonyl-4H-quinolizin-4-one (1 g) in chloroform (20 ml) was added trimethylsilyl iodide (0.49 ml) at room temperature and the mixture was stirred for 4 hours and heated with reflux for 4 hours. After cooling to room temperature, the mixture was washed with water, aqueous sodium thiosulfate, and brine. Drying over magnesium sulfate and evaporation gave a crystalline residue, which was washed with isopropyl alcohol to give 1-ethoxycarbonyl4H-quinolizin-4-one-3-carboxylic acid (794 mg).

1. temperatureheated
2. temperaturewith reflux for 4 hours
3. washthe mixture was washed with water, aqueous sodium thiosulfate, and brine
4. dry with materialDrying over magnesium sulfate and evaporation
5. customgave a crystalline residue, which
6. washwas washed with isopropyl alcohol