1,4-Dibromobutane → HCID 178464532, compound

HRID 25560Notes

Reaction equation

HRID 25560 reaction equation
[CH2:1]([N:3]([C@H:17]1[CH2:22][CH2:21][C@H:20]([OH:23])[CH2:19][CH2:18]1)[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2].[Br:24][CH2:25][CH2:26][CH2:27][CH2:28]Br>>[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][O:23][C@H:20]1[CH2:19][CH2:18][C@H:17]([N:3]([CH2:1][CH3:2])[S:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:9][CH:8]=2)(=[O:5])=[O:6])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 178464531HCID 178464531, compound

Product 1

HCID 178464532HCID 178464532, compound

Procedure

In analogy to example 11.11, trans-N-Ethyl-N-(4-hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide and 1,4-Dibromobutane were converted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-N-ethyl-4-trifluoromethyl-benzenesulfonamide as colorless oil, MS 470 (M−CH3, 1Br).

Sources & evidence

ORD record
ord-41e57c42536c47388bfbf00bbc448463
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

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