HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4H-quinolizin-4-one-1,3-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate | HCID 262620 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4H-quinolizin-4-one-1,3-dicarboxylic acid | HCID 13921245 | 28% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a solution of 1,3-diethoxycarbonyl-4H-quinolizin-4-one (896 mg) in methanol (9 ml) was added 6N aqueous sodium hydroxide (2.58 ml) at room temperature and the mixture was heated with reflux for an hour. After cooling to 0° C., the reaction mixture was acidified to pH 2 with 6N hydrochloric acid and the precipitate was filtered and washed with water to give 4H-quinolizin-4-one-1,3-dicarboxylic acid (202 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04698349 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-93a652526910429c87415cb6447a0262 |
| Source note | uspto-grants-1987_10 |