Hydrochloric Acid → HCID 178522688, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-ethoxycarbonyl-N-(1H-tetrazol5-yl)-4H-quinolizin-4-one-3-carboxamide (500 mg) in N,N-dimethylformamide (5 ml) was added 1N aqueous sodium hydroxide (6 ml) at room temperature and the mixture was heated at 100° C. for an hour. After cooling to 0° C., the mixture was acidified to pH 2 with 6N hydrochloric acid and the precipitate was filtered and washed with water to give 1-carboxy-N-(1H-tetrazol-5-yl)-4H-quinolizin-4-one-3-carboxamide (280 mg).

Provenance & Evidence