Hydrazine hydrate (1:1) → HCID 178445973, compound

Participants

Reaction Steps

134 mg (0.2 mmole) of ethyl 4(S)-[N-benzyloxycarbonyl-3-(1-naphthyl)-L-alanyl-L-histidyl]amino-3(S)-hydroxy-6-methylheptanoate (prepared as described in Example 1) were dissolved in 2 ml of dimethylformamide, and 100 mg (2 mmole) of hydrazine hydrate were added to the resulting solution, which was then stirred at room temperature for 2 days. The solvent was then removed by distillation under reduced pressure, and water was added to the resulting residue to form a precipitate, which was filtered off. The resulting precipitate was washed thoroughly with water and then dissolved in methanol. The solvent was removed by distillation under reduced pressure. A 1:1 by volume mixture of diethyl acetate and diethyl ether was added to the resulting solid residue, which was then finely pulverized and filtered. There were obtained 112 mg of the title compound as a white powdery solid, melting at 120°-127° C., [α]24 -58.6°. (C=0.5, dimethylformamide).

Provenance & Evidence