HCID 178500762, compound → HCID 14010717, compound

Participants

Reaction Steps

In 15 ml of N,N-dimethylformamide was dissolved 2.0 g of methyl 5-(4-chlorophenyl)-2-(4-fluorophenylaminomethylene)-3-oxo-4-pentenoate, and they were reacted at 140° C. for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the residue was purified by a column chromatography (Wako Silica Gel C-200; eluent: benzene/ethyl acetate (3:1 by volume) mixture) to obtain 1.1 g of oily methyl 6-(4-chlorophenyl)-1-(4-fluorophenyl)-4-oxo-1,4,5,6-tetrahydronicotinate.

Provenance & Evidence