Acetic Acid → HCID 15591095, compound

HRID 255635Notes

Reaction equation

HRID 255635 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH:10]=[C:11]([C:16](=[O:18])[CH:17]=2)[C:12]([O:14]C)=[O:13])=[CH:4][CH:3]=1.C(O)(=O)C>CO.[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)[CH:10]=[C:11]([C:16](=[O:18])[CH:17]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 15590980HCID 15590980, compound

Product 1

HCID 15591095HCID 15591095, compoundYield 83.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

In a mixed solvent of 5 ml of methanol and 5 ml of 1N aqueous sodium hydroxide solution was dissolved 0.5 g of methyl 6-(4-chlorophenyl)-1-(4-fluorophenyl)-4-oxo-1,4-dihydronicotinate, and they were reacted at room temperature for 30 minutes. After completion of the reaction, the reaction mixture was adjusted to a pH of 5.5 with acetic acid, and the precipitated crystals were collected by filtration, washed with 10 ml of water and dried to obtain 0.4 g of 6-(4-chlorophenyl)-1-(4-fluorophenyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 199°-204° C.

Workup

  1. customwere reacted at room temperature for 30 minutes
  2. customAfter completion of the reaction
  3. filtrationthe precipitated crystals were collected by filtration
  4. washwashed with 10 ml of water
  5. customdried

Sources & evidence

ORD record
ord-316d6fe848f5426b95f7ccd67082386f
Source dataset
uspto-grants-1987_10
Patent number
US04698352

Reaction notes

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