Acetic Acid → HCID 15591134, compound

Participants

Reaction Steps

In a mixed solvent of 10 ml of ethanol and 10 ml of a 10% by weight aqueous sodium hydroxide solution was dissolved 0.5 g of methyl 1-(4-acetaminophenyl)-6-(2-naphthyl)-4-oxo-1,4-dihydronicotinate, and the solution was refluxed for 3 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, and diluted with 20 ml of water. This solution was then adjusted to a pH of 5.5 with acetic acid, and the precipitated crystals were collected by filtration, washed with water, and dried to obtain 0.38 g of 1-(4-aminophenyl)-6-(2-naphthyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 148°-151° C.

Provenance & Evidence