Acetic Anhydride → HCID 54547794, compound

Participants

Reaction Steps

To 0.7 g of 1-(4-fluorophenyl)-6-methyl-4-oxo-1,4-dihydronicotinic acid was added 0.33 g of isonicotinaldehyde and 0.61 g of acetic anhydride, and they were refluxed for 5 hours. After completion of the reaction, 30 ml of water was added to the reaction mixture, and the mixture was successively extracted with three 30-ml portions of chloroform. The chloroform layer was separated, washed with 20 ml of a saturated aqueous solution of sodium chloride, and then dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to obtain 0.42 g of 1-(4-fluorophenyl)-6-[2-(pyridin-4-yl)ethenyl]-4-oxo-1,4-dihydronicotinic acid having a melting point of 205°-215° C.

Provenance & Evidence