Acetic Acid → HCID 15591175, compound

HRID 255654Notes

Reaction equation

HRID 255654 reaction equation
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)[CH:13]=[C:14]([C:19](=[O:21])[CH:20]=2)[C:15]([O:17]C)=[O:16])=[CH:7][CH:6]=1)C(C)=O.C(O)(=O)C>CO.[OH-].[Na+]>[NH2:1][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)[CH:13]=[C:14]([C:19](=[O:21])[CH:20]=2)[C:15]([OH:17])=[O:16])=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 15591004HCID 15591004, compound

Product 1

HCID 15591175HCID 15591175, compoundYield 80.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

In 3 ml of methanol and 5 ml of 10% by weight aqueous sodium hydroxide solution was dissolved 0.5 g of methyl 6-(4-acetaminophenyl)-1-(3-pyridyl)-4-oxo-1,4-dihydronicotinate, and they were reacted at 60° C. for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and adjusted to a pH of 6.0 with acetic acid, and the precipitated crystals were collected by filtration, washed with 10 ml of water, and then dried to obtain 0.34 g of 6-(4-aminophenyl)-1-(3-pyridyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 207°-208° C.

Workup

  1. customwere reacted at 60° C. for 4 hours
  2. customAfter completion of the reaction
  3. filtrationthe precipitated crystals were collected by filtration
  4. washwashed with 10 ml of water
  5. customdried

Sources & evidence

ORD record
ord-db0196efc22e4f1da50d6bfb124a39b3
Source dataset
uspto-grants-1987_10
Patent number
US04698352

Reaction notes

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