HCID 14010733, compound → HCID 14010737, compound

Participants

Reaction Steps

5 ml of methanol was carefully added to 0.06 g of 5% by weight palladium carbon under ice cooling, and this mixture was stirred under a hydrogen atomosphere at room temperature for 20 minutes, followed by addition of a solution of 0.4 g of methyl 6-(1-benzyloxycarbonyl-4-piperidinyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinate in 2 ml of methanol, and the mixture was subjected to hydrogenation under atmospheric pressure for 4 hours. After completion of the reaction, the palladium carbon was removed by filtration and the solvent was removed by distillation under reduced pressure to obtain 0.24 g of methyl 6-(4-piperidinyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinate having a melting point of 226°-228° C.

Provenance & Evidence