HCID 20183830, compound → HCID 14010764, compound

Participants

Reaction Steps

In a mixture of 10 ml of dioxane and 5 ml of water was dissolved 0.15 g of 6-(4-benzyloxycarbonylaminocyclohexyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinic acid, and 0.03 g of 5% by weight palladium carbon was added. The above acid was hydrogenated under atmospheric pressure for 3 hours. The catalyst was removed by filtration and the solvent was then removed by distillation under reduced pressure. To the residue was added 3 ml of diethyl ether, and the precipitated crystals were collected by filtration and washed with 3 ml of diethyl ether to obtain 0.095 g of 6-(4-aminocyclohexyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 237°-250° C. (decomp.).

Provenance & Evidence