Nitric Acid → Glyoxylic Acid

HRID 255679Notes

Reaction equation

HRID 255679 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[CH:5]([CH:7]=[O:8])=[O:6]>>[C:7]([OH:2])(=[O:8])[CH:5]=[O:6].[N+:1]([O-:4])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 944Nitric Acid2×HCID 7860Glyoxal

Product 2

HCID 760Glyoxylic AcidHCID 944Nitric Acid

Procedure

If nitric acid is added sequentially to an aqueous solution of glyoxal so that the nonoxidizing strong acid is kept at a concentration of 6 wt. % or higher in the reaction mixture, the reaction can proceed in a state wherein nitric acid is not present in the reaction solution in a concentration exceeding 1 wt. %, and an aqueous solution of glyoxylic acid having a final residual nitric acid concentration of 0.1 wt. % or below can be easily obtained. Thus, it is possible to omit the step of removing residual nitric acid, which step is conventionally required, and to use the aqueous solution of glyoxylic acid obtained by the process of the invention directly in further synthesis reactions.

Workup

  1. customthe reaction
  2. concentrationis not present in the reaction solution in a concentration

Sources & evidence

ORD record
ord-7bf30ae73c8c4b4eb224eaafbc4b2215
Source dataset
uspto-grants-1987_10
Patent number
US04698441

Reaction notes

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