Formaldehyde → HCID 22619060, compound

Participants

Reaction Steps

In a manner analogous to that described hereinabove, 1 mol of nitroethane is added slowly to 2 mols of isopropylamine to form the salt intermediate, and thereafter 2 mols of paraformaldehyde are slowly added to the salt with stirring which is continued for 4 hr. The conversion of the nitroethane to 2-nitro-2-methyl-1,3-di(isopropylamino)propane is in excess of 90 mol %. The reaction mixture is then diluted with 250 ml of i-PrOH and hydrogenated in a manner analogous to that described hereinabove, to yield 2-amino-2-methyl-1,3-di(isopropylamino)propane the conversion of which is in excess of 90 mol % based on the nitroethane charged.

Provenance & Evidence