Tert-Butyl hypochlorite → 1,1-Di(p-fluorophenyl)-3-chlorourea

HRID 255689Notes

Reaction equation

HRID 255689 reaction equation
[Cl:1]OC(C)(C)C.[F:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:15]([NH2:17])=[O:16])=[CH:10][CH:9]=1>CO>[F:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:15]([NH:17][Cl:1])=[O:16])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 521297Tert-Butyl hypochloriteHCID 133624301,1-Di(p-fluorophenyl)urea

Product 1

HCID 201841521,1-Di(p-fluorophenyl)-3-chlorourea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

t-Butyl hypochlorite (22.8 g, 0.21 mole) was added to 1,1-di(p-fluorophenyl)urea (49.4 g, 0.2 mole) in 750 ml methanol at 0°-5° and the mixture stirred for 0.5 hour to produce a thin slurry containing step (a) title product.

Workup

  1. customto produce a thin slurry

Sources & evidence

ORD record
ord-4d1cd14642234994b333ea2c45f471db
Source dataset
uspto-grants-1987_10
Patent number
US04698444

Reaction notes

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