Triethylamine → HCID 178469226, compound

Participants

Reaction Steps

A mixture of ethyl 2-[2-(4-chlorobenzyloxy)-benzylidene]acetoacetate (10 g), acetamidine hydrochloride (3.16 g), and triethylamine (4.23 g) in n-butanol (100 ml) was refluxed for 3.5 hours. The reaction mixture, added ethyl acetate (100 ml), was washed with water (100 ml) and 5% hydrochloric acid (100 ml) successively. The solvent was evaporated and the residual crystalline was stirred with ethyl acetate (50 ml) for 1 hour. The crystals were collected by filtration dried in vacuo to afford ethyl 2,4-dimethyl-6-[2-(4-chlorobenzyloxy)phenyl]-1,6-dihydro-5-pyrimidinecarboxylate hydrochloride (2.45 g).

Provenance & Evidence