Water → HCID 15147491, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (0.24 g) in dry tetrahydrofuran (40 ml) was dropwise added a solution of ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (2.0 g) in the same solvent (20 ml) under cooling at 7°-9° C. After the addition was completed, the mixture was stirred for 2 hours at room temperature. The excess lithium aluminum hydride was decomposed by a careful addition of water and the dried solution was concentrated in vacuo to an oil. The oil was column chromatographed on silica gel eluting with chloroform and the fractions containing a produce were collected and concentrated in vacuo. The residual crystals were recrystallized from n-hexane to give 5,6-dimethyl-2-phenyl-4-(4-pyridyl)pyrimidine (0.03 g), mp 152°-153° C.

Provenance & Evidence