HCID 135838358, compound → HCID 135838359, compound

Participants

Reaction Steps

A mixture of 4-(4-hydroxy-3-nitrophenyl)-6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-2-phenylpyrimidine (0.8 g) and 10% Palladium on carbon (0.2 g) in methanol (30 ml) was hydrogenated at room temperature under atmospheric pressure. After removal of the catalyst by filtration, the filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (100 g) and eluted with a mixture of chloroform and methanol (30:1). The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from diethyl ether to give 4-(3-amino-4-hydroxyphenyl)-6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-2-phenylpyrimidine (0.2 g).

Provenance & Evidence