Hydrochloric Acid → 7-[2-(2-Aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid hydrochloride

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A mixture of 7-[2-(2-formamidothiazol-4-yl)-2-(2-formyloxyethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 3.1 g.), conc. hydrochloric acid (1.35 g.), tetrahydrofuran (23.0 ml.), and methanol (23.0 ml.) was stirred at room temperature for 6.5 hours. After concentrating the resultant solution in vacuo, methanol (50 ml.) was added to the residue. After concentrating the solution to a half volume of the initial, the precipitates were collected by filtration, washed with diethyl ether and dried to give 7-[2-(2-aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid hydrochloride (syn isomer, 0.71 g.).

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