Hydrochloric Acid → HCID 131715306, compound

Participants

Reaction Steps

N.M.R. δ(DMSO-d6, ppm): 3.3-3.9 (4H, m), 4.1-4.8 (4H, m), 5.23 (1H, d, J=5Hz), 5.84 (1H, dd, J=5 Hz, 9 Hz), 7.63 (1H, s), 8.72 (1H, s), 9.57 (1H, s), 9.71 (1H, d, J=9 Hz), 12.71 (1H, broad s). (2) A mixture of 7-[2-(2-formamidothiazol-4-yl)-2-(2-bromoethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.5 g.), conc. hydrochloric acid (0.99 g.), tetrahydrofuran (10 ml.) and methanol (22 ml.) was treated in similar manner to that of Example 9 (2), to give 7-[2-(2-aminothiazol-4-yl)-2-(2-bromoethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.15 g.).

Provenance & Evidence