HRID255793

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCCON=C(C(=O)O)c1csc(NC=O)n1

HCID54082885

未命名化合物

结构：C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1

HCID70432653

未命名化合物

PRODUCTS

生成物

结构：C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCCNC(=O)OC(C)(C)C)c3csc(NC=O)n3)[C@H]2SC1

HCID131715325

未命名化合物

收率 95.4%

PROCEDURE

实验过程

2-(2-Formamidothiazol-4-yl)-2-(2-tert-butoxycarbonylaminoethoxyimino)acetic acid (syn isomer, 2 g.) and 7-amino-3-(1-allyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (2 g.) were treated in a similar manner to that of Example 20-(1) to give 7-[2-(2-formamidothiazol-4-yl)-2-(2-tert-butoxycarbonylaminoethoxyimino)acetamido]-3-(1-allyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 3.7 g.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ba4b7876aee24ee5acc983afb35296bf
来源数据集: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04698337
来源说明: uspto-grants-1987_10

反应 SMILES

[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][CH2:15][CH2:16][NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:10]([OH:12])=O)[N:8]=1)=[O:2].[NH2:25][CH:26]1[C:46](=[O:47])[N:28]2[C:29]([C:43]([OH:45])=[O:44])=[C:30]([CH2:33][S:34][C:35]3[N:39]([CH2:40][CH:41]=[CH2:42])[N:38]=[N:37][N:36]=3)[CH2:31][S:32][C@H:27]12>>[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][CH2:15][CH2:16][NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:10]([NH:25][CH:26]2[C:46](=[O:47])[N:28]3[C:29]([C:43]([OH:45])=[O:44])=[C:30]([CH2:33][S:34][C:35]4[N:39]([CH2:40][CH:41]=[CH2:42])[N:38]=[N:37][N:36]=4)[CH2:31][S:32][C@H:27]23)=[O:12])[N:8]=1)=[O:2]