Dicyclohexylcarbodiimide → HCID 15587193, compound

HRID 255803Notes

Reaction equation

HRID 255803 reaction equation
[C:1]([CH2:4][S:5][CH:6]([C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH2:12][CH2:11][N:10]=1)[C:7]#[N:8])(O)=[O:2].C1(N=C=NC2CCCCC2)CCCCC1>N1C=CC=CC=1>[C:7]([C:6]1[S:5][CH2:4][C:1](=[O:2])[N:10]2[CH2:11][CH2:12][C:13]3[C:18](=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)[C:9]=12)#[N:8]

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 15587171HCID 15587171, compound

Product 1

HCID 15587193HCID 15587193, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a pyridine solution of 3.2 g. of α-(carboxymethyl-mercapto)-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile 2.1 g. of dicyclohexyl-carbodiimide are added. The reaction mixture is allowed to stand at room temperature for two days. The solvent is evaporated in vacuo and the residue is recrystallized from butanol. 1.9 g. of 1-cyano-9,10-dimethoxy-3,4,6,7-tetrahydro-1,4-thiazino[3,4-a]isoquinoline-4-one are obtained, melting at 186° to 187° C. after recrystallization from butanol.

Workup

  1. customThe solvent is evaporated in vacuo
  2. customthe residue is recrystallized from butanol

Sources & evidence

ORD record
ord-a0f5fde7fcb84790b8ac0514fca99d95
Source dataset
uspto-grants-1987_10
Patent number
USRE032519

Reaction notes

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