Acetic Anhydride → HCID 15587193, compound

HRID 255804Notes

Reaction equation

HRID 255804 reaction equation
[C:1]([CH2:4][S:5][CH:6]([C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH2:12][CH2:11][N:10]=1)[C:7]#[N:8])(O)=[O:2].C(OC(=O)C)(=O)C>N1C=CC=CC=1>[C:7]([C:6]1[S:5][CH2:4][C:1](=[O:2])[N:10]2[CH2:11][CH2:12][C:13]3[C:18](=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)[C:9]=12)#[N:8]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15587171HCID 15587171, compound

Product 1

HCID 15587193HCID 15587193, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 3.2 g. of α-(carboxymethyl-mercapto)-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile 15 ml. of pyridine and 15 ml. of acetic anhydride are added. The solution is allowed to stand at room temperature for two days. 2.8 g. of 1-Cyano-9,10-dimethoxy-3,4,6,7-tetrahydro-1,4-thiazino[3,4-a]isoquinoline-4-one are obtained in a crystalline form. The product is identical with the product of Example 24.

Sources & evidence

ORD record
ord-e4e9f101a06f448aa00de6cc6aa9093d
Source dataset
uspto-grants-1987_10
Patent number
USRE032519

Reaction notes

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