Hydrazine hydrate (1:1) → 1-[2-(Hydrazinecarbonyl)phenyl]methanesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a suspension of 84 g of methyl 2-[(aminosulfonyl)methyl]benzoate in 300 ml of absolute ethanol was added dropwise 22 g of hydrazine monohydrate. The thick suspension was heated at reflux for about 16 hours to yield a solution, then a thick suspension, at reflux temperature. The suspension was cooled to 20° C. filtered, and the residue was washed 1×100 ml of water and suction dried about three hours to provide 49 g of the subject compound; m.p. 221°-222° C.

Provenance & Evidence