HCID 20164613, compound → HCID 20164683, compound

Participants

Reaction Steps

A mixture of 2.0 g of α-(2,4-dichlorobenzyl)-α-(1-methoxyvinyl)-3-pyridinemethanol (see Example 3, 2nd end product), 0.2 g of hydrogenation catalyst (5% palladium on carbon) and 40 ml of acetic acid is stirred for 7 hours at room temprature under a hydrogen atmosphere at normal pressure. Thereafter, the hydrogenation catalyst is removed by filtration, the filtrate is freed from solvent under reduced pressure, the residue is taken up in a saturated sodium bicarbonate solution and the solution is extracted with ethyl acetate. The organic phase is evaporated and the residue is crystallized from methylene chloride/n-hexane. In this manner there is obtained α-(2,4-dichlorobenzyl)-α-(1-methoxyethyl)-3-pyridinemethanol as colorless crystals, m.p. 94°-95° C.

Provenance & Evidence