Potassium Cyanide → HCID 13959015, compound

Participants

Reaction Steps

1.0 g of potassium cyanide was added to a stirred solution of 4.4 g of 53F in 60 ml of dry DMF at room temperature, under nitrogen. The mixture was stirred overnight at room temperature, under nitrogen, then 200 mg potassium cyanide was added and the mixture was stirred for 5 hours at room temperature. The mixture was quenched in water and filtered. The solid was dissolved in ethyl acetate, the solution was washed with water, dried (MgSO4), filtered and stripped of solvent, to give 4-cyano-8-ethylcinnoline (53G), as a yellow solid, m.p.: 102°-104° C., with decomposition.

Provenance & Evidence