Beta-Alanine → 2-Methyl-1[4-(2-nitro-1-propenyl)-phenyl]-imidazole

HRID 255908Notes

Reaction equation

HRID 255908 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.[N+:15]([CH2:18][CH3:19])([O-:17])=[O:16].NCCC(O)=O>C(O)CCC>[CH3:1][C:2]1[N:3]([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=[C:18]([N+:15]([O-:17])=[O:16])[CH3:19])=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1

Participants

5

Reactant 3

HCID 239Beta-AlanineHCID 6587NitroethaneHCID 31596624-(2-Methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 545510292-Methyl-1[4-(2-nitro-1-propenyl)-phenyl]-imidazole

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Similar to example 4(a), the reaction is carried out with 66 g 4-(2-methyl-1-imidazolyl)-benzaldehyde (DE-OS No. 33 06 196), 31.7 g nitroethane, 3.2 g β-alanine and 250 ml n-butanol.

Sources & evidence

ORD record
ord-5c22e4443e334c6d911976bad035c7ba
Source dataset
uspto-grants-1987_10
Patent number
US04699914

Reaction notes

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