HCID 70363414, compound → HCID 70363193, compound

Participants

Reaction Steps

A solution of 400 mg of (5Z,13E)-(9R, 11R,15RS)-11,15-bis(tetrahydropyran-2 -yloxy)-9-fluoro-15-methyl-5,13-prostadienoic acid methyl ester in 50 ml of ethyl acetate is shaken with 40 mg of pa 11adium/10% strength on carbon under a hydrogen atmosphere at 0° C. After absorption of 1 equivalent of hydrogen, the product is filtered off from the catalyst and evaporated under vacuum. The residue is absorbed on silica gel. With hexane/5-20% diethyl ether, 300 mg of the title compound is eluted as a colorless oil.

Provenance & Evidence