Diethyl Ether → HCID 131715333, compound

Participants

Reaction Steps

Solid 1-fluoro-2-bromomethyl-3-phthalimidopropene (0.60 g) is added to a previously prepared mixture of 2,4-dichlorophenol (0.33 g) and sodium hydride dispersion (96 mg of 55-60% oil dispersion) in dimethylformamide (10 ml) at room temperature. Stirring is continued for 3 hours, then brine is added and the product is isolated by ether extraction. The extracted material is essentially pure (Z)-1-fluoro-(2',4'-dichlorophenoxy)methyl -3-phthalimidopropene (0.67 g; 88% yield). A small portion is recrystallized from hexane/dichloromethane whereupon the analytical sample is obtained as colorless plates; mp. 115°-116° C.

Provenance & Evidence