Cyclopropylamine → HCID 178471868, compound

Participants

Reaction Steps

33.4 g of ethyl 3-dimethylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate are heated to boiling under reflux with 7 g of cyclopropylamine and 120 ml of toluene for 1 hour. The gas evolution, the onset of which is initially violent, is then finished. The toluene is removed by distillation in vacuo, and the solid residue is recrystallized from light petroleum. 32.5 g of ethyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate of melting point 89°-91° C. are obtained.

Provenance & Evidence