HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 178500745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Methyl 3-(1-pyrrolidinyl)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate | HCID 53739964 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178500745 | HCID 178500745 | 74.4% |
Reaction Steps
3.5 g of methyl 3-(1-pyrrolidinyl)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate are heated to boiling under reflux with 0.8 g of cyclopropylamine and 50 ml of toluene for one hour. The toluene is removed by distillation in vacuo, and the residue is recrystallized from acetonitrile. 2.5 g of methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate of melting point 150°-151° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699992 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-d4ed08f1b0db45a994199dacb27f8bbb |
| Source note | uspto-grants-1987_10 |