Sodium Hydroxide → HCID 13958721, compound

Participants

Reaction Steps

A mixture containing 69 g of dimethyl 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate, 300 ml of methanol and 100 ml of 35% aqueous sodium hydroxide solution was refluxed with stirring for 5 hours and then allowed to stand at room temperature overnight. The methanol was removed using a rotary evaporator and to the residual liquid was added 200 ml of water and filtered. The filtrate was acidifed with concentrated hydrochloric acid whereupon there precipitated a cream colored solid, which was washed with water and dried at 80°-85° C. to yield 52.6 g (88%) of 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid, m.p. >285° C.

Provenance & Evidence