Hydrochloric Acid → HCID 18610521, compound

Participants

Reaction Steps

170 mg of α-{6(R)-[(R)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 4) were dissolved in 0.8 ml of a 1% w/v aqueous solution of sodium hydroxide, and the resulting solution was allowed to stand for 18 hours at room temperature. 0.8 ml of 1N hydrochloric acid was added dropwise to this reaction product, and the pH of the mixture was adjusted to the value of 2.0. The title compound was precipitated as a powder following the dropwise addition; this was separated and washed with a small amount of water and ethyl acetate, to yield 70 mg of the title compound.

Provenance & Evidence