Trifluoroacetic acid → alpha-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl)acetic acid

Participants

Reaction Steps

160 mg of isomer B of t-butyl α-{6(R)-[1-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetate [prepared as described in Example 16(h)] were subjected to de-t-butylation with trifluoroacetic acid in the manner described in Example 3, to give 118 mg of the title compound as an amorphous solid.

Provenance & Evidence