HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → alpha-{6(R)-[1(S)-Carboxy-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | alpha-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl)acetic acid | HCID 13877956 | — |
| Product | alpha-{6(R)-[1(S)-Carboxy-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid | HCID 13877958 | 76.7% |
Reaction Steps
90 mg of α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 17 above) were hydrolyzed with aqueous sodium hydroxide in the manner described in Example 5, to give 65 mg of the title compound as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-1016936beed34ca68b334382fd938268 |
| Source note | uspto-grants-1987_10 |