Trifluoroacetic acid → alpha-{6(R)-[1(S)-Butoxycarbonyl-3-phenylpropylamino]-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid

Participants

Reaction Steps

100 mg of isomer B of t-butyl α-[6(R)-(1-butoxycarbonyl-3-phenylpropylamino)-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetate (prepared as described in Example 23) was treated with trifluoroacetic acid to remove its t-butyl group in the same manner as in Example 3. 60 mg of the title compound were obtained as an amorphous solid.

Provenance & Evidence